The ASsessment, Serial Evaluation and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Consortium

In 2007, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) released an Request For Applications (DK-07-009 “Ancillary Studies in the Natural History of Acute Kidney Injury”) to create a multi-center research consortium to address these knowledge gaps by expanding our understanding of the natural history of patients suffering from AKI. The Assessment, Serial Evaluation and Subsequent Sequelae of Acute Kidney Injury (ASSSESS-AKI) consortium was established in 2008 to compare prospectively differences in the occurrence of renal and cardiovascular outcomes and death within a diverse, matched cohort of patients with and without AKI. The overall goals of ASSESS-AKI are to:

  • Establish a diverse prospective, parallel, matched cohort of adults and children with and without AKI.
  • Characterize the short-term and long-term natural history of AKI based on current serum creatinine-based diagnostic criteria.
  • Evaluate the incremental utility of novel blood and urine biomarkers to refine the diagnosis and prognosis of AKI.
  • Develop a prognostic risk model that integrates patient characteristics and biomarkers to help inform providers and patients about the risks of adverse events after an episode of AKI.
  • Identify the subset of high-risk patients who could be targeted for future interventional clinical trials to improve outcomes after an episode of AKI.
    • The ASSESS-AKI Study will leverage ongoing studies involving patients undergoing cardiac surgery or in the intensive care unit and expand the study population to include a more general hospitalized population to provide a broadly representative study of the natural history of AKI.

ASSESS Site Locations

Kaiser Permanente of Northern California
(Oakland, CA; San Francisco, CA; Walnut Creek, CA; Hayward, CA)

University of Washington
(Seattle, WA)

Vanderbilt University
(Nashville, TN)

Yale University
(New Haven, CT; Cincinnati, OH; London, Ontario; Montreal, Quebec)

Data Coordinating Center (DCC)
(The Pennsylvania State University (Hershey, PA))

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
(Bethesda, MD)

ASSESS-AKI site location map

© The Pennsylvania State University 2013